Date / 02/08/2018

US $1-20 CXCR3 is a 7-TM GPCR that is selective for the CXC chemokines IP10, I-TAC and MIG. Binding of IP10 and MIG to CXCR3 induces Ca2+ mobilization, chemotaxis and inflammatory responses of T lymphocytes, and also act as potent inhibitors of angiogenesis. CXCR3 is highly expressed in IL-2-activated T lymp...

Related Keywords: Human CXCR3/Galpha15 Stable Cell Line-Chem-1

Date / 02/08/2018

US $1-20 CXCR2 is a 7-TM G-protein coupled receptor that binds to the chemokines GROalpha, GRObeta, GROgamma, IL-8, ENA-78, NAP-2 and GCP-2. Neutrophils, mast cells and microvascular endothelial cells express CXCR2, and interactions of CXCR2 with its ligands promotes chemotaxis of these cell types. Studies w...

Related Keywords: Human CXCR2/Galpha15 Stable Cell Line-Chem-1

Date / 02/08/2018

US $1-20 CXCR1 (also known as IL-8RA) is a Gi/o-coupled GPCR expressed on neutrophils, CD8(+) T cells, and intestinal epithelial cells. CXCR1 binds with high affinity to the chemokine interleukin-8 (IL-8) and much lower affinity to GROalpha, whereas a related receptor, CXCR2, binds with equal affinity to IL-...

Related Keywords: Human CXCR1/Galpha15 Stable Cell Line-Chem-1

Date / 02/08/2018

US $1-20 CX3CR1 is a GPCR expressed on natural killer cells, cytotoxic T lymphocytes, and macrophages. The sole ligand for CX3CR1, fractalkine, is an unusual chemokine that is expressed as a transmembrane molecule with a CX3C domain and a mucin domain. Fractalkine is highly expressed on endothelial cells act...

Related Keywords: Human CX3CR1/Galpha15 Stable Cell Line-Chem-4

Date / 02/08/2018

US $1-20 This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein pre...

Related Keywords: Human CCR8/Galpha15 Stable Cell Line-Chem-1

Date / 02/08/2018

US $1-20 CCR7 is a GPCR that binds to CC chemokine ligands MIP-3beta (ELC/CCL19) and 6Ckine (CCL21). These ligands are expressed in the secondary lymphoid organs, and binding to CCR7 expressed in naive T cells, B cells and dendritic cells directs migration of these cells to sites of antigen presentation. Inh...

Related Keywords: Human CCR7/Galpha16 Stable Cell Line-Chem-1

Date / 02/08/2018

US $1-20 CCR5 is the receptor for CC chemokines MIP-1alpha, MIP-1beta, and RANTES, and is preferentially expressed on Th1 lymphocytes. CCR5 is a coreceptor for macrophage-tropic HIV, and its ligands potently inhibit HIV replication in human leukocytes. In addition, HIV-infected patients with the nonfunctiona...

Related Keywords: Monkey CCR5/Galpha15 Stable Cell Line-Chem-1

Date / 02/08/2018

US $1-20 CCR4 is a GPCR that is activated by chemokines TARC (thymus and activation regulated chemokine) and MDC (macrophage-derived chemokine). NK cells, Th2 cells, cutaneous memory T cells, macrophages and platelets express CCR4 and respond to TARC and MDC. CCR4-null mice display reduced airway hyperrespon...

Related Keywords: Human CCR4/Galpha15 Stable Cell Line-Chem-5

Date / 02/08/2018

US $1-20 Cholecystokinins are a series of peptides of heterogeneous length (5 to 58 amino acids) that are derived from preprocholecystokinin and are found in gastrointestinal tissues and the central nervous system. Gastrin is a related peptide with 5 C-terminal amino acids identical to those of cholecystokin...

Related Keywords: Human CCKBR/Galpha15 Stable Cell Line-Chem-1

Date / 02/08/2018

US $1-20 Cholecystokinins are a series of peptides of heterogeneous length (5 to 58 amino acids) that are derived from preprocholecystokinin and are found in gastrointestinal tissues and the central nervous system. Gastrin is a related peptide with 5 C-terminal amino acids identical to those of cholecystokin...

Related Keywords: Human CCKAR/Galpha15 Stable Cell Line-Chem-1